tag:blogger.com,1999:blog-12660458.post113086198416462845..comments2023-09-01T10:33:09.297-04:00Comments on Pulmonary Roundtable: Pancytopenia, abnormal cxrUnknownnoreply@blogger.comBlogger4125tag:blogger.com,1999:blog-12660458.post-1130879366177286662005-11-01T16:09:00.000-05:002005-11-01T16:09:00.000-05:00I'd love to hear from some of the non-regulars out...I'd love to hear from some of the non-regulars out there!!!Jeff Hhttps://www.blogger.com/profile/01209432708535732499noreply@blogger.comtag:blogger.com,1999:blog-12660458.post-1130879324733520582005-11-01T16:08:00.000-05:002005-11-01T16:08:00.000-05:001. No, that is not enough for sarcoid. The diffe...1. No, that is not enough for sarcoid. The differentials listed (endemic fungi, HP, Collagen-vascular associated ILD) have not been excluded. Lymphoma is unlikely, although we don't really know how long the mediastial LAD has been there. <BR/><BR/>2. No, the BAL does not exclude infection, although as Mike and Carlos noted, I doubt active infection in the lung now, if present, would be related to the pancytopenia. I'll also note that while she is not absolutely neutropenic, we don't know if her white cells "work" normally.<BR/><BR/>Has HIV been checked?<BR/><BR/>3. As Carlos noted, a low CD4/CD8 (less than 2) would support HP, while a high ratio can be seen with sarcoid. But, I would not pin any diagnoses on this.<BR/><BR/>4. See #1 above. <BR/><BR/>5. The pancytopenia sounds like it's been stable over the years, but the lung findings have progressed. Not sure they are directly related. I think a bone marrow biopsy AND a surgical lung biopsy should be done.Jeff Hhttps://www.blogger.com/profile/01209432708535732499noreply@blogger.comtag:blogger.com,1999:blog-12660458.post-1130878365974801162005-11-01T15:52:00.000-05:002005-11-01T15:52:00.000-05:001. I agree with ML, I would not be satisfied with ...1. I agree with ML, I would not be satisfied with sarcoid as the only Dx.<BR/>2. I don't think that "incomplete" BAL sampling rules out infection.<BR/>3. If the cell count had a predominance of CD8s with that loose granuloma, HP could account for some of the parenchymal changes and sarcoid would be less likely the cause.<BR/>4. I think there are two questions on the DDx: what caused the pancytopenia in the first place? and are the infiltrates caused by the same entity? At age 24 (onset of pancytopenia) there are several possibilities: drug-exposure such as "huffing" toluene/benzene can lead to this presentation but she would not have lived this long. Same for AML. Viral etiologies don't seem to fit well either: Parvo B19 should be self-limited and HIV and HEPC would have progressed after 10 years... Young adults with aplastic anemia due to one of the agents above can progress to MDS and that might explain her protracted course. PNH could also explain this presentation though they tend to have renal and thromboembolic Dz too. Maybe the mosaic appearance with the Pulm HTN are due to chronic VTE due to PNH (check a Ham test).<BR/>5. "Chronic" histo for 10 years with stable bone marrow disease seems an unusual presentation...<BR/>For Mike's sake, visceral Leishmaniasis will cause this picture of pancytopenia though I doubt she has been bitten by sandflies in the Middle East or South America...Baleeirohttps://www.blogger.com/profile/03993066135160692535noreply@blogger.comtag:blogger.com,1999:blog-12660458.post-1130875118264612052005-11-01T14:58:00.000-05:002005-11-01T14:58:00.000-05:00Cool case.She needs a bone marrow anyway to w/u he...Cool case.<BR/>She needs a bone marrow anyway to w/u her pancytopenia (I would not assume that is sarcoid related), and this will likely show granulomas. Also, culture of the BMBx is pretty sensitive and specific for fungal disease in a setting of pancytopenia. It would be hard to believe that she had active histo for 10 years without getting worse, however. You could send serologic fungal studies if you think it may be helpful. The BMBx would be all that I would need.<BR/><BR/>If she is afebrile, I would not be inclined to BAL her again. If it was positive for S. Aureus, would you treat? I would not. She should not have gradual dyspnea with a pulmonary infection.<BR/><BR/>A CD4/CD8 would not be helpful.<BR/><BR/>Other things in the DDx: CVD with associated ILD. I cannot think of anything else. Maybe CEOB has a worm/parasite in mind.Mike Lhttps://www.blogger.com/profile/12177750268091750583noreply@blogger.com