Question came in from here:
Just a quick question on alfa-1 antitrypsin replacement.
Do you use weekly regimen or monthly regimen? FDA has approved only once a week regimen. But I have read that monthly regimen is also "widely used in many centers." What is your experience on this? Monthly regimen would be off-label use. Has anybody experienced a severe adverse effect with monthly regimen?
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The less than handful patients I have had were on augmentation Tx were on weekly infusion...
Some people do monthly because it is more convenient but last I did a quick review on this, I seem to remember that this is less effective than the weekly regimens.
A new study in Thorax suggests every 2 or 3 weeks may be feasible.
http://thorax.bmj.com/cgi/content/abstract/61/12/1059
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