Distant F/up and question

I had posted the CxR on this 68 y/o man back in May: he had COPD and B/L upper lobe disease with M. kansasii. He was started on INH/RIF/ETH and did fairly well: cough resolved and his CxR improved. However he came to the ER last night with some confusion, N&V and FTT. His AST was ~300 with ALT~150 (ammonia was only 5). We have held his meds. I suspect that, similar to TB Tx, I will be able to reintroduce them at a lower dose and monitor. However, in case I cannot reintroduce the INH, any experience with or suggestion of alternative regimens?