From a PCP in NC:
"Quick question: what PFT parameter is the last to normalize (if it ever does) in patients with ARDS, 1 year out?" The pulmonary boards were yesterday so some of you fellows out there should have no problem with this question.....
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There are surprisingly little data regarding long-term changes in pulmonary function following ARDS. Most data suggest that (in survivors), there is steady improvement and normalization in FEV1, and FVC, for about a year following ARDS. The DLCO seem to improve at similar rates, but after a year the DLCO remains mildly impaired in this population.
--Herridge et al. NEJM 2003
--Lee and Hudson, Seminars in Respiratory and Critical Care Medicine 2001
--Neff et al. Chest 2003
A recent report shows that "at 12 months, lung spirometry tests demonstrated mild abnormalities that were stable over time (64% and 49% had <80% predicted forced expiratory volume in 1 sec [Fev1] and forced vital capacity [Fvc], respectively)."
--Heyland, Crit Care Med. 2005 Jul;33(7):1549-56.
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